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Vitamin B6: Though some research suggests vitamin B6 could help alleviate some of the emotional symptoms of PMDD, the small amount in this supplement is most likely added to help the body better metabolize the supplemental 5-HTP into serotonin.64 65 Lions mane: While research is still emerging, lions mane may help support mood and reduce inflammation.66 The amount included here is relatively modest compared to doses used in clinical studies, so it likely plays more of a supporting role in the formula
These formulas have been shown to be effective in the treatment of certain conditions
The sample size was selected in accordance with previous studies using comparable models and endpoints, which reported adequate statistical power to detect treatment-related differences while minimizing animal use in compliance with the 3Rs principle 32
