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10.1016/j.isci.2024.109778 iScience 38 ChenY.-J.WangW.-F.JhangK.-M.ChangM.-C.ChangC.-C.LiaoY.-C

By targeting the Nrf2 signaling pathway with compounds, such as osthole, 5-hydroxymethyl-2-furfural (5-HMF), and paeonol, researchers have effectively reduced oxidative damage and BBB permeability in mouse models of ischemia (Zhao et al., 2014

Accordingly, the levels of CBS protein were also reduced after 48 h but not after 24 h of treatment (Figure 4D)