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FAQs Why do some patients struggle to stick with GLP-1 or Metformin for managing PCOS symptoms
Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity
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Green tea or matcha
However, newer multi-hormone weight-loss drugs that target additional receptors beyond GLP-1 are currently in clinical trials
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