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When compared to those taking topiramate, GLP-1 users were: 48% less likely to start valproate 42% less likely to start calcitonin gene-related peptide (CGRP) monoclonal antibodies 35% less likely to start tricyclic antidepressants 23% less likely to start the class of drugs called gepants However, there was no significant difference between the two groups, and the need to begin taking beta-blockers

Some areas of investigation may include: Multi-receptor signalling models Experimental studies examining how the peptide interacts across multiple receptor pathway models within structured laboratory settings

MECHANISM OF ACTION: A dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist activates both the GIP and GLP-1 receptors, and as a result it effectively regulates glucose levels, reduces appetite and promotes weight loss

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