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CYP-Mediated Pharmacokinetic Interaction: The Unknown Variable Venlafaxine is primarily metabolized by CYP2D6 to its active metabolite O-desmethylvenlafaxine (desvenlafaxine), with CYP3A4 contributing a minor pathway [3]
all were exposed to systemic glucocorticoids, and N=1165 (41%) developed new or worsening hyperglycaemia in those who had diabetes at baseline
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