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Additionally, combining semaglutide with other GLP-1 receptor agonists (such as dulaglutide, liraglutide, or tirzepatide) significantly increases the risk of severe nausea, vomiting, and gastrointestinal complications
Preclinical and clinical studies have demonstrated that GLP-1 receptors expressed in myocardial and vascular endothelium tissue play a fundamental role in the cardioprotective effect of GLP-1 RAs, lowering the risk of major cardiovascular events, heart failure, and kidney complications in adults with and without diabetes [4]
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