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4 Interactions of MEVs with the gut microbiome The gut microbiome comprises more than 100 trillion commensal microorganisms, including bacteria, archaea, fungi, and protozoa, residing in the human gastrointestinal tract (Ley et al., 2006)

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The ensuing phagocytosis of RBCs may lead to iron overload within macrophages, which has been shown to cause progressive macrophage dysfunction, inflammatory M1 polarization, increased ferroptosis and exacerbated atherosclerosis 66,67,68,69,70,71

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Wittrup, A

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SNAP23 is required for constitutive and regulated exocytosis in mouse oocytes

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