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IGF-1 LR3 remains an agonist of the IGF-1 receptor, but it has very low affinity for IGFBPs, which inhibit IGF-1, making it more potent
Toxicol Sci 142:436444 Xia J, Wishart DS (2011) Web-based inference of biological patterns, functions and pathways from metabolomic data using metabo analyst
These effects relate directly to growth hormone elevation and typically resolve with dose adjustment
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