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Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals
Hallmarks of aging: an expanding universe
By clearing out senescent cells, FOXO4-DRI decreases the production of inflammatory signals, promotes tissue repair, and restores a healthier cellular environment, effectively reducing chronic inflammation and its negative effects on the body (7)
The underlying literatures remain separate and each is preclinical for musculoskeletal endpoints
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