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This was because hydroxocobalamin produced by bacteria was changed to cyanocobalamin during purification in activated charcoal columns after separation from the bacterial cultures (because cyanide is naturally present in activated charcoal)

The lungs of mock-treated control hamsters showed severe pathological changes, which were evidenced by large areas of consolidation as well as cell infiltrations in the endothelium of blood vessels, and peribronchiolar regions