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Accordingly, SDH flux showed lower conversion into M2-fumarate in Gclc fl/fl Mb1-Cre + FoB compared to control cells (Supplementary Fig

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This is proposed to be mediated by TRX1 oxidation by hydrogen peroxide which causes dissociation of ASK1 thereby triggering anti-apoptotic factors via downstream activation of MAPK kinase MKK3/MKK6/p38 and MKK4/MKK7/JNK pathways (Wagner et al