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The germinal center B-cell-like (GCB) subtype of diffuse large B-cell lymphoma (DLBCL) is highly sensitive to the ferroptosis inducer dimethyl fumarate (DMF) due to low GPX4 expression and high 5-LOX expression (163)
The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells
The class traces back to a discovery in the early 1990s
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