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In addition, because the WT, gGT , and gGT :: gGT strains exhibited uniform growth kinetics when cultured individually (Fig 3B), and all strains were similarly viable when co-cultured with AGS cells (S3 Fig), the observed changes in host GSH levels were not due to differences in the viability of the tested strains
Therefore, it is possible to continuously generate a large amount of hydrogen in the large intestine, in which the environment is neutral to weakly alkaline, by oral administration of the Si-based agent
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Critical when clearance kinetics and downstream effects are the primary endpoints
