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Both of these pathophysiological phenomena result in increased intestinal calcium absorption and increased bone calcium resorption

Among nonsteroidal anti-inflammatory drugs, aspirin dissociates mitochondrial-bound HK2 by disrupting its interaction with VDAC1, 1179 whereas diclofenac suppresses GLUT1 and HK2 activity, thus reducing glycolysis

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If headaches become frequent or severe, notify your healthcare provider before your next dosedose timing or strength adjustments may help