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The GIPR rs1800437 variant affects glucose-dependent insulinotropic peptide signaling, another pathway central to appetite and weight regulation
Garcia-Echeverria et al (2004) presented a new compound (a pyrrolo[2,3-d] pyrimidine) that although inhibiting the IGF-1R and IR TK equipotently in cell-free systems, exhibited several-fold selectivity for the IGF-1R in a cellular context and reduced the growth of IGF-1R positive fibrosarcomas in vivo
PMID 24918645
Conclusions To sum up, GLP-1 has extensive effects based on its biological characteristics through binding to GLP-1R
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