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Lee D, Arvizu P, Pfeil A, Suarez E, Hill L

These drugs are primarily prescribed for the management of type 2 diabetes mellitus and, more recently, for weight management in adults with obesity or overweight with weight-related comorbidities

The recommended starting point for finding UK trials is: NIHR Be Part of Research (bepartofresearch.nihr.ac.uk) the UK's public-facing portal for finding and joining clinical research studies ClinicalTrials.gov and the EU Clinical Trials Register international registries of ongoing studies, including the REDEFINE and TRIUMPH programmes Referral via a GP or specialist to a trial centre In the meantime, men with obesity or type 2 diabetes should be aware that NICE-approved treatments are already available and may offer meaningful clinical benefit: Semaglutide (Wegovy) is approved by NICE (TA875) for weight management in adults with a BMI 35 kg/m (or lower thresholds for certain ethnic groups) and at least one weight-related comorbidity, subject to specialist tier service criteria and duration requirements

Prescription medications that mimic GLP-1 activity have been shown to produce significant results but may come with side effects and accessibility limitations