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Fluid retention and edema: During treatment with glucocorticoids and diclofenac, edema and fluid retention have been observed so the formula must be used with caution in patients with a history of decompensation, hypertension or other factors predisposing to fluid retention

Preclinical literature frequently references cellular and animal models involving connective tissue response, soft tissue remodeling, and inflammatory pathway modulation when examining these peptides individually or in combination