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Helps reinforce mindful eating and portion awareness
XIGDUO XR is contraindicated in severe renal impairment, patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m [see DOSAGE AND ADMINISTRATION , CONTRAINDICATIONS , WARNINGS AND PRECAUTIONS , and CLINICAL PHARMACOLOGY ]
Inside visceral fat, an enzyme called 11-beta-HSD1 converts inactive cortisone into active cortisol locally, creating a pool of fat-derived cortisol on top of whatever the adrenals produce (PMC7827500, Fella Health)
Future research should explore not only who responds to GLP-1 RA pharmacotherapy, but also how to maintain progress once medication ends, especially in vulnerable subgroups
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