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Nevertheless, poor diet, toxins, medications, stress, and illness can deplete its levels

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On the other hand, exposure to hypobaric hypoxia decreased the ATP and NADPH level in hippocampus which could be a result of impaired mitochondrial functioning on account of reduced availability of oxygen and malfunctioning of the pentose phosphate pathway that generate NADPH and/or overutilization of NADPH under hypoxic condition [26]

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