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These include: daprodustat (GSK1278863) and vadadustat (AKB-6548), and the reference name of molidustat, BAY 85-3934
10.1016/j.neuropharm.2018.06.030 Neuropharmacology
2023;9(2):e13129
These data indicate that the disulfide bonds of both E127 ECD CQ211 ECL1 C and Q37 ECD CL379 ECL3 C are formed on the native protein in the absence of the antibody, strengthening the hypothesis that the current structure represents a physiologically relevant inactive conformation of GLP-1R
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