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They found that overexpression of miR-145 led to inhibition of IGF-1-induced cell proliferation and miR-145 was shown to directly bind to 3UTR of IGF-1R and IRS-1 in the bladder cancer cells
While these studies show promising results, they often lack the rigor and relevance required to extrapolate findings to human subjects
Additionally, those seeking alternatives to conventional sedative-hypnotics due to tolerance, dependency, or adverse side effects could be potential candidates
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