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But you should talk to your doctor first if you have: Severe GERD thats hard to control Barretts esophagus (a condition that increases cancer risk) Esophageal strictures (narrowing of the throat) A history of stomach or intestinal problems Gastroparesis (stomach paralysis) Your doctor will help you decide if semaglutide is right for you or if you need a different treatment
Preferential tissue distribution to kidneys, liver, and gastrointestinal tract aligns with observed therapeutic effects in animal studies
Conversely, in a review of six clinical trials, researchers found that tirzepatide has a bigger impact on the absorption of oral contraceptives compared to other GLP-1s
