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Proc Natl Acad Sci 101:37803785
4 Materials and methods 4.1 Antibodies and reagents The antibodies to PTEN (#9559), AKT (#9272) and p-AKT (#4060) were purchased from Cell Signaling Technology (Danvers, MA, USA)
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This antioxidative effect is also observed with caffeine and paraxanthine [10], which are known to upregulate endogenous antioxidant systems [43], thereby protecting neurons from oxidative damage [44]
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