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Remarkably, while inhibiting GLP-1R-expressing neurons in the AP prevents the aversion caused by exendin-4 and semaglutide, the chronic inhibitory effects of the two GLP-1R agonists on food intake and body weight are preserved [34, 58]

Beyond their blood sugar-lowering effects, certain medicationssuch as liraglutide, semaglutide, and tirzepatidehave demonstrated significant effectiveness in promoting weight management, and they have been approved by the Food and Drug Administration (FDA) for long-term obesity treatment

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