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Conformational flexibility of the ECLs Structural superimposition of the ligand-free G s -coupled GLP-1R, GCGR and GIPR with those bound by endogenous peptides reveals that the ligand-binding pocket of ligand-free receptor is partially occupied by GCGR ECL2 or GIPR ECL3 but not the ECLs of GLP-1R

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Current data remains too limited to definitively confirm or rule out fetal risks, so discontinuation is the safest first step

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