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To account for the pronounced heterogeneity of the preclinical evidence base, specific inclusion criteria for preclinical studies were defined as follows: (1) Model Type: utilization of established in vivo models (e.g., transgenic AD models like APP/PS1 or 3xTg-AD, neurotoxin-induced PD models, middle cerebral artery occlusion for ischemia, or high-fat diet for metabolic dysfunction) or relevant in vitro neuronal/glial cell lines
Gastrointestinal Healing: Alcohol abuse is known to cause significant damage to the gastrointestinal (GI) tract, leading to inflammation, ulcers, and impaired digestive function
Based on the recorded data, none of the patients included in the present study had 3 of the 5 diagnostic criteria of metabolic syndrome
Nishimura, T
