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Johns wort [ Hypericum perforatum ]), fisetin (found in many fruits and vegetables), chlorogenic acid (found in coffee and several foods), and hesperidin and naringenin (found in citrus fruits)
This hormone stimulates insulin secretion, inhibits glucagon release, and slows gastric emptying
Science 372 , eabe7729 (2021)
The peptide's resistance to dipeptidyl peptidase-IV (DPP-IV) proteolysis is achieved through substitution of -methyl-Phe at position 2, which blocks the cleavage of the Tyr1Ala2 bond that normally inactivates native incretins within minutes of secretion
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