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The endothelial deficiency of Pcsk5 resulted in a marked reduction in both capillary and arteriole densities in the ischemic limbs of mice (Fig

Interestingly, because apoptosis is used by the host as an antiviral defense strategy in order to eliminate virus, HSV-1 encodes numerous viral determinants for evading it (Figure 2A), which overall may favor virus persistence in the host by remaining in a viable substrate as a long-term niche for latency, which could produce chronic inflammation due to recurrent asymptomatic reactivations (Perng et al., 2000)