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Through the inhibition of phosphoinositide 3-kinase (PI3K), 3-MA disrupts the formation of autophagosomes, thereby impeding the initiation of the autophagic process
Macrophages undergo metabolic switching during differentiation into inflammatory (M1) or anti-inflammatory (M2) phenotypes
Statistical analysis was performed by t -test (unpaired or paired, as indicated), one-way analysis of variance (ANOVA), two-way ANOVA (time treatment or genotype treatment) with post hoc comparisons (where appropriate, as indicated in the figure legends)
