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Description

Appetite suppression is well-established at this stage, and meaningful weight loss is typically underway

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These agents bind within deep transmembrane pockets of the receptor, often exhibit stimulatory G protein alpha subunit (Gs)-biased signaling that can limit -arrestin-driven internalization, and are designed for food-independent, once-daily dosing

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[1] Regarding pregnancy, tirzepatide should be discontinued when pregnancy is recognized

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