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How often IV B12 is given can vary from weekly to monthly, depending on how the patient responds and the reason for the deficiency
After reconstitution, the solution should remain refrigerated at 28C and protected from freeze-thaw cycles, which can cause peptide aggregation and measurable loss of bioactivity
If the patient is suspected to be sensitive to cobalt or other components of cobalamin, an intradermal test dose is recommended
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