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Retatrutides safety profile is based on Phase 2 trial data only

A large multicenter study (n = 1,513) demonstrated that integrating proteomic (alpha-2-macroglobulin, cathepsin D, CD324) and metabolomic (galactose, glycerolipid pathways, glycerol-3-galactoside) data substantially improved classification precision versus single-omics approaches (Zeng et al., 2025)

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The FDA A 2022 review of 38 studies suggests these injections are generally safe and effective but may cause local swelling and pain for a few days following treatment