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Conversely, Melatonin, investigated for its potential antioxidant effects, failed to demonstrate significant improvement in outcomes for STEMI patients undergoing PCI in the MARI trial ( The overall mixed clinical results for exogenous antioxidants underscore significant challenges in translating preclinical success, largely contributing to their unmet promise. These hurdles include poor pharmacokinetics and bioavailability, leading to insufficient concentrations at the injury site, and a critical lack of specificity

The science underpinning today's biggest commercial launches often starts far from the companies that bring them to market, and the chain of talent involved stretches across discovery, development, regulatory, and beyond, a reminder of just how many people it takes to get a pill to market

This is not harmful in most cases