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J Am Chem Soc (2021) 143:76472
They remain effective throughout this window
Injection site reactions are the most common issue, presenting as redness, mild swelling, or a small knot at the injection site
However, there is still a significant difference between the WL that can be achieved with bariatric surgery and the currently approved obesity pharmacotherapies and there is heterogeneity in treatment responses with GLP-1 RA (for example people with T2D may achieve less WL compared to those without diabetes in clinical trials, despite similar lifestyle interventions) [13, 14]
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