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However, the understanding of the stereochemistry of the MSA-DH reaction is crucial for the elucidation of the overall carnitine degradation pathway: L-malate might be directly channeled into the tricarboxylic acid cycle whereas D-malate would require a specific oxidation step that potentially yields the central metabolite oxaloacetate or pyruvate
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Myc-Tag (Cell signaling)
Mechanistically, multi-omics analyses of cardiac and hepatic tissues revealed that semaglutide exerted these benefits by improving cardiac metabolism, interfering with pro-fibrotic and pro-hypertrophic signals, and by reducing systemic inflammation
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