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MEN1, a key driver of pancreatic neuroendocrine tumors (pNETs), suppresses SCD1 expression by inhibiting mTOR, resulting in a decrease in MUFAs such as oleic acid (OA) and ultimately promoting lipid peroxidation and ferroptosis in pNETs
The C20 fatty diacid moiety enabling albumin binding extends the pharmacokinetic half-life to approximately 6-7 days, making once-weekly research dosing protocols practical
10.1016/j.taap.2023.116440 211 QiuW.AnS.WangT.LiJ.YuB.ZengZ.et al (2022)
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