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It typically resolves within a few hours and many patients don't find it bothersome
In this post-analysis of 327 participants, the average weight loss after 68 weeks was 17.3% with semaglutide and 2% with placebo
Sleep hygiene: Lack of sleep increases ghrelin (the hunger hormone), making the wearing off effect feel much worse
During the first four weeks after starting tirzepatide or after dose increases, patients might consider non-oral emergency contraception options like ulipristal acetate (ella) or a copper IUD if accessible, particularly if they have concerns about absorption or have higher BMI
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