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A major challenge relates to the heterogeneity of clinical presentation, making it difficult to recognize thyroid disorders at their inception (Mallhi et al
Altogether, these findings indicate that the antioxidant effects of metformin are achieved by Nrf2 nuclear translocation, increased downstream cytoplasmic HO-1 expression, and the subsequent activation of Nrf2 dependent signaling pathway
Regular follow-ups allow the medical team to track progress, make necessary adjustments, and address any questions or concerns
Another study suggested the existence of a correlation between NRF2 accumulation and the development of a multisystemic disorder, characterized by immunodeficiency and neurological symptoms [322]
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