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Quick fixes and crash diets often result in temporary success followed by rapid regain, leaving many people frustrated and discouraged

doi: 10.1038/s41581-020-00384-1 12 LeeJMKronbichlerAShinJIOhJ

Future studies should explore the dynamic interactions among SIRT1, mTOR, autophagy, and endoplasmic reticulum (ER) stress to elucidate its regulatory functions under varying metabolic states, guiding the development of targeted interventions for early-stage MASLD-related metabolic disorders