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Preclinical studies have suggested potential biomarkers such as circulating free IGF levels, mutations of p53, BRCA1, KRAS and BRAF, IRS2 copy number gain, InsR/IGF-IR overexpression, InsR/IGF-IR pathway activation, PTEN loss, CD24, mesenchymal markers, -catenin/TCF activity, FUS-DDIT3 fusion, and ERG [192,193,194,195,196,197,198,199,200,201]
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Ensure adequate protein intake (generally 0.8-1.0 grams per kilogram of body weight daily per US Dietary Guidelines, though patients with chronic kidney disease should follow their healthcare provider's specific recommendations)
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