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The most commonly mentioned effects include mild nausea in some users (typically transient), injection site reactions (redness, minor discomfort), mild headache or dizziness (uncommon), and sleep disruption with late-day dosing (reported by some users)

Its binding constant (pKa 16.44) is similar to albumin's copper transport site (log = 16.2), allowing GHK to exchange copper with albumin for intracellular delivery.[3] Discovery and design rationale GHK was first identified in 1973 in fractions of human plasma that promoted survival of liver cells in culture