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For optimal nasal absorption, dosing protocols recommend waiting up to one minute between sprays to the same nostril, maintaining a tilted head position while spraying, and clearing any nasal congestion prior to administration
However, both frequency of administration and the timing of administration in relation to other treatments such as social cognition training may be important for efficacy
In such cases, an injection bypasses the gut and delivers B12 directly into the bloodstream
people with known cardiovascular disease, arrhythmia, or uncontrolled hypertension (chronic high-dose human data do not exist)
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