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Weiland A, Wang Y, Wu W, Lan X, Han X, Li Q, et al

Clin Res Hepatol Gastroenterol 44(5):674680

Opioid-induced adrenal insufficiency is estimated to affect approximately 15% of patients treated with opioids for at least three to six months

However, insufficient data are available to support the use of these agents instead of insulin in critically ill patients with T2DM and COVID-19, especially if the therapy needs to be initiated under conditions of severe illness (Fig