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(1996, NEJM, n=32 healthy adults aged 64-81) showed that 25 mg oral MK-677 daily increased mean 24-hour GH pulse amplitude and elevated IGF-1 by roughly 40% compared to baseline over two weeks
Oral NR (strongest human RCT base) Multiple RCTs (Martens 2018, Conze 2019, Dollerup 2018, Brakedal 2022) consistently raised blood NAD+ with favorable tolerability at doses up to 1,000 mg/day
GHK-Cu has a broader research history involving collagen, tissue repair, extracellular matrix remodeling, inflammation, antioxidant activity, and skin health
In case of emergencies, stock up on naloxone
