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Medicine-food herbs against alzheimers disease: A review of their traditional functional features, substance basis, clinical practices and mechanisms of action
The hydrogen bond has been suggested to act as a gate, restricting entry of the solvent molecule into the active site and also regulating access of the substrate to the active site cleft that results in a rigid structural conformation around the binding pocket
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If folate deficiency is present, replacement should only be started after initiating B12 therapy to avoid worsening neurological symptoms
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