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Minor TR, g WC, and Winslow JL
Under exposure to Tat, cocaine, or ART, lysosomal dysfunction is observed: lysosomal pH rises, lysosome-associated membrane protein 2 (LAMP2) decreases, and cathepsin D decreases
joint involvement with pain/swelling/erythema), in the context of the patients history, with supporting evidence of elevated serum urate levels at a time other than during an acute attack Elevated serum urate levels alone are not diagnostic of gout, but may inform lifestyle changes (if relevant) and subsequent follow-up testing Treat gout flares with a NSAID, prednisone or low-dose colchicine
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