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Beyond cardiac and kidney benefits, in people with type 2 diabetes and metabolic-associated steatotic liver disease a network meta-analysis indicated that each one of GLP-1 receptor agonists and SGLT-2 inhibitors have a favourable effect on liver steatosis [42], thereby paving the way for evaluating combination regimens for this indication
Under type 2 (T2) conditions (IL-13 stimulation), human airway epithelial cells (HAECs) generate oxidized phospholipids under control of the 15 lipoxygenase 1 (15LO1) enzyme and its binding with phosphatidylethanolamine-binding protein 1 (PEBP1) (6)
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