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A metabolic pathway parallel to glycolysis that utilizes enzymes, including G6P, to generate NADPH and ribose 5-phosphate, the latter of which can be used for nucleotide synthesis

It is given once weekly via a subcutaneous injection and works by activating both GLP-1 and GIP receptors a dual-action approach that produced among the most significant weight loss results seen in any modern clinical trial

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

Novo Nordisks Peter Johannsen, MD, highlighted the biological signals observed and acknowledged the clinical limitations: subgroup analyses did not reveal meaningful benefit, and any potential responder group would be very small