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As for another cooperative factor, ATF4 activation has a synergistic effect with NRF2 activation on xCT expression (Ye et al
The breadth of DSIPs biological activity spanning sleep regulation, stress modulation, pain processing, antioxidant defence, and neuroprotection has led some researchers to characterise it as an adaptogenic peptide: one that supports homeostatic balance across multiple physiological systems rather than acting on a single discrete target
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