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Animal study context The animal studies that drive the pregnancy warnings used tirzepatide in pregnant rats and rabbits during organogenesis
Pantethine, a naturally occurring compound synthesized in the body from pantothenic acid via addition of cysteamine, which acts as an intermediate in the production of coenzyme A, can also be a source of pantothenate because it is highly unstable in serum, and it is rapidly converted to pantothenate and cysteamine [40, 41]
Other factors impacting bone health may include cellular changes, genetic damage due to complex age-related changes as well as nutritional deficiencies of calcium and vitamin D
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